 | Jun 1, 2005
By:Christopher J. Welch, William R. Leonard Jr., Jimmy O. DaSilva, Mirlinda Biba, Jennifer Albaneze-Walker, Derek W. Henderson, Brian Laing, David J. Mathre
This month's installment of "Column Watch" provides an overview of green chemistry considerations for the kilogram-scale preparative chromatographic separation of enantiomers, focusing especially on recent results from the authors' laboratories, illustrating solvent and time savings realized with preparative supercritical fluid chromatography (SFC). They compare optimized high performance liquid chromatography and SFC in terms of energy efficiency and throughput.
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Jun 1, 2002
By:Andreas Brandt, Stephan Kueppers
Two contrasting dynamics in the pharmaceutical industry are furthering interest and method development in preparative high performance liquid chromatography (HPLC). On one hand, regulatory agencies continue to press for more...
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