 | Sep 1, 2005
By:Larry J. Burge, Christina M. Sorgen
Here the authors discuss an ion-pair, gradient HPLC method, developed for cycloserine-related substances using a polar, amide-embedded C18 column. Other polar-embedded and polar-endcapped columns are evaluated in equivalence studies.
 |
 | Jun 1, 2005
By:Michael P. Balogh
In this initial installment of "MS - The pRactical Art," a new series of columns is introduced that investigates various aspects of mass spectrometry (MS) from the perspective of some leading practitioners. Here featured scientists Kathleen Cox and Timothy Baker discuss several MS technologies and strategies currently being applied to characterize drug candidates in early stage development.
|
Jun 1, 2005
By:Ronald E. Majors
Recently, the subject of green chemistry has received considerable
attention from academic and industrial researchers alike. While the central tenets of waste reduction, process economy, and elimination of risks and...
|
 | Jun 1, 2005
By:Kolbjorn Zahlsen, Trond Aamo, Jerry Zweigenbaum
LC-MS monitoring of the drug clozapine is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale drug monitoring program.
|
 | Sep 1, 2004
By:Michael Swartz, Ira Krull
Michael Swartz and Ira Krull outline the ways in which forced degradation is used to develop a stability-indicating method and examine some of the method development and validation parameters critical to its success.
|
Sep 1, 2002
By:Jeffrey R. Mazzeo, Eric S. Grumbach, Steven Collier
The authors describe a method development approach that incorporates four packing materials with unique selectivities. They found that using different packing materials and mobile-phase pH levels was the most powerful...
|
Jun 1, 2002
By:Andreas Brandt, Stephan Kueppers
Two contrasting dynamics in the pharmaceutical industry are furthering interest and method development in preparative high performance liquid chromatography (HPLC). On one hand, regulatory agencies continue to press for more...
|
Mar 1, 2002
By:Shane R. Needham
Parallel synthetic techniques (1) and parallel biological screening (2) place tremendous time constraints upon analytical chemists to provide results in a rapid fashion. The mass selectivity of liquid chromatographymass...
|
| 
