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Method Development

Peak Tailing and Resolution

Sep 1, 2002

Resolution is a measurement used to quantify peak spacing in a liquid chromatography (LC) separation. Although very simple at first examination, resolution can be affected significantly by peak sizes and...

A Four-Column Approach to Developing Stability-Indicating HPLC Methods

Sep 1, 2002

The authors describe a method development approach that incorporates four packing materials with unique selectivities. They found that using different packing materials and mobile-phase pH levels was the most powerful...

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