 | Sep 1, 2006
By:John W. Dolan
There always seems to be one more way an LC system can fail.
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 | Jun 1, 2006
By:John W. Dolan
John Dolan delves deeper into dwell volume, a subject that was touched upon in a recent installment of "LC Troubleshooting."
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 | Mar 1, 2006
By:John W. Dolan
This "LC Troubleshooting" installment will take a look at pump design, how check valves work, and what steps can be taken to minimize pump problems.
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 | Sep 1, 2005
By:John W. Dolan
This month's installment of "LC Troubleshooting" covers some techniques to help determine the reason these wide peaks are seen.
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 | Sep 1, 2005
By:John W. Dolan
Some simple practices will help to make problems with gradient methods rare rather than frequent. This month's installment of "LC Troubleshooting" presents a baker's dozen of these tips.
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 | What's Under the Tail?
Jun 1, 2005
By:John W. Dolan
John Dolan presents some possible solutions to the ubiquitoous peak-tailing problem.
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Mar 1, 2005
By:Jonathan J. Gilroy, John W. Dolan
Gradient elution is used widely both in research and production liquid chromatography (LC) separations. For routine analyses of drugs in biological matrices, our laboratory prefers to use gradient elution...
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Nov 1, 2004
By:John W. Dolan
The following question is typical of many that readers e-mail to me: "I am trying to transfer a validated method from another lab. The method uses a...
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Sep 1, 2004
By:John W. Dolan
This month's "LC Troubleshooting" column is inspired by a reader's question I received recently. She asked me what system-suitability tests were required for a liquid chromatography (LC) method. Unfortunately, this is...
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