Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Process Research

This month's installment of "Column Watch" provides an overview of green chemistry considerations for the kilogram-scale preparative chromatographic separation of enantiomers, focusing especially on recent results from the authors' laboratories, illustrating solvent and time savings realized with preparative supercritical fluid chromatography (SFC). They compare optimized high performance liquid chromatography and SFC in terms of energy efficiency and throughput.